Description
Product Characteristics:
The annexin family of calcium-binding proteins is composed of at least ten mammalian genes. It is characterized by a conserved core domain, which binds to phospholipids in a Ca2+-dependent manner, and a unique amino terminal region, which may confer binding specificity. The annexin family has been implicated as regulators of such diverse processes as ion-flux, endocytosis and exocytosis, and cellular adhesion. Two forms of Annexin XI, designated A and B, have been identified. Transfection of COS-7 cells with Annexin XI-A, but not Annexin XI-B, causes formation of Annexin XI-associated vesicles.
Subcellular location: Cytoplasm, Nucleus
Synonyms: 56 kDa autoantigen, Annexin A11, Annexin XI, Annexin-11, AnnexinA11, AnnexinXI, ANX 11, ANX A11, ANX11, ANX11_HUMAN, ANXA 11, ANXA11, Autoantigen 56 kD, Calcyclin associated annexin 50, Calcyclin-associated annexin 50, CAP 50, CAP-50, CAP50, OTTHUMP00000059806.
Target Information: This gene encodes a member of the annexin family, a group of calcium-dependent phospholipid-binding proteins. Annexins have unique N-terminal domains and conserved C-terminal domains, which contain the calcium-dependent phospholipid-binding sites. The encoded protein is a 56-kD antigen recognized by sera from patients with various autoimmune diseases. Transcript variants encoding the same isoform have been identified. [provided by RefSeq, Jul 2008]